Trial Results and Publications

Prognostic factors for poorer outcome, particularly baseline stroke severity and treatment delay, improve the power of demonstrating the treatment effect of MLC601.

  • Prognostic Factors and Pattern of Long-Term Recovery with MLC601 in CHIMES-E study.
    Full publication

Beneficial effect of MLC601 in Filipino cohort is durable up to 2 years after stroke.

  • Durability of beneficial effect of MLC601 on functional recovery among stroke patients from the Philippines in the CHIMES and CHIMES-E studies.
    Full publication

Trend for a higher proportion with good functional outcome with NeuroAiD is seen in Female gender.

  • Gender and treatment effect in CHIMES study- This was published in November 2016 in Journal of Clinical Neuroscience.
    Abstract highlight

Use of the Original full version NIHSS to evaluate patients’ stroke severity is recommended

  • Comparison Between the Original and Shortened Versions of the National Institutes of Health Stroke Scale in Ischemic Stroke Patients of Intermediate Severity.
    Full publication

Patients who have moderately severe strokes and longer Onset to Treatment Time (OTT) demonstrate better treatment effects with MLC601.

  • The value of patient selection in demonstrating treatment effect in stroke recovery trials: Lessons from the CHIMES study of MLC601.
    Full publication

CHIMES-E Study results

  • CHInese Medicine NeuroAiD Efficacy on Stroke Recovery – Extension Study (CHIMES-E): A Multicenter Study of Long-Term Efficacy
    Full publication

Patients with 2 or more predictors of poorer outcome have better treatment effect with MLC601 than patients with single or no prognostic factor.
[Predictors of poorer outcome -Age, Sex/Gender, Baseline National Institutes of Health Stroke Scale score and Time to first dose]

The SPAN-100 [Stroke Prognostication using Age and National Institutes of Health Stroke Scale (NIHSS)] index can predict functional outcome following ischemic stroke across its spectrum.

  • Using the full span of the SPAN-100 index to predict functional outcome in the CHIMES Study.
    Full publication

Treatment Response of Patients from the Philippines in the CHIMES Study

  • Baseline characteristics and treatment response of patients in the Philippines in the CHIMES study.
    Full publication

Reduction of Early Vascular Events in Patients After Stroke: (The CHIMES Study)

  • Effects of MLC601 on Early Vascular Events in Patients After Stroke.
    Full publication

Primary paper on CHIMES Study: NeuroAiD at acute and sub-acute stage of stroke and meta-analysis updated

  • Chinese Medicine Neuroaid Efficacy on Stroke Recovery: A Double-Blind, Placebo-Controlled, Randomized Study.
    Full publication

Systematic Review of NeuroAiD in Poststroke Recovery

  • Efficacy and Safety of MLC601 (NeuroAiD), a Traditional Chinese Medicine, in Poststroke Recovery: A Systematic Review.
    Full publication

MLC601 is safe in acute stroke patients undergoing 3 months of treatment.

  • Safety Profile of MLC601 (Neuroaid) in Acute Ischemic Stroke Patients: A Singaporean Sub study of the Chinese Medicine Neuroaid Efficacy on Stroke Recovery.
    Full publication