Clinical Research
To date, a number of publications in peer reviewed journals support the use of NeuroAiD™ in stroke recovery and selected neurosurgical pathologies as a safe and effective medicine at the chronic stage of stroke.
- Clinical trials on 605 patients recruited between 2 weeks and 6 months after their stroke shows that subjects taking NeuroAiD™ are 2.4 times more likely to regain independence and achieve an average of 25% higher recovery in motor functions versus subjects receiving another well established traditional medicine.(Stroke 2009)
- A double blind placebo controlled clinical trial which was conducted on 150 subjects having suffered from stroke less than 3 months previously. NeuroAiDTMshowed a better motor recovery than placebo, and was safe as an add-on therapy to standard ischemic stroke medications, especially in severe and moderate cases.(Stroke Research and Treatment , 2011)
- Neuroaid triggers a significant increase of Cerebral Blood Flow velocity after 3 months treatment. These results, which was associated with a better functional outcome, suggested increased angiogenesis and microcirculation activity as mechanisms of recovery (European Journal of Internal Medicine, 2011)
- NeuroAiDTM may increase the recovery of vision deficits in post stroke Homonymous Hemianopsia patients. The patients in NeuroAiDTMgroup demonstrated a 50% increase in therapeutic effects as compared to the Piracetam group (Neuronal Regeneration Research, 2011)
- Case reports on 10 patients who received NeuroAiD after ischemic stroke onset confirmed on imaging recorded a variety of improvements (motor, gait, cognitive) (European Neurology 2009)
- In a double-blind, placebo-controlled, randomized phase II pilot study to investigate the potential efficacy of the traditional Chinese medicine NeuroAiD (MLC 601) in enhancing recovery after stroke (TIERS), treatment was initiated less than one month post ischemic stroke. NeuroAiD performed better in severe cases (+58% compared to the Placebo panel) and in best responders group (+39% better recovery than in placebo panel) (Cerebrovascular Disease, 2009)
Safety Profile
Neuroaid has well established safety profile. Several clinical trials have established its excellent tolerability both at acute and chronic stages;
- Biochemical, haematological and electrocardiogram tests demonstrated that NeuroAiD is as safe as a placebo for stroke patients receiving a 3- month treatment in a sub study of an ongoing randomized placebo controlled trial.Analysis of various physiological parameters demonstrates and confirms that NeuroAiD is safe in acute stage stroke patients – Cerebrovascular Diseases 2009
- NeuroAiD does not significantly affect hematological, hemostatis, and biochemical, in normal and stroke patients. Clinical parameters and expected effect of aspirin are not altered by co-administration of the drug even when started and maintained at the early stage of acute stroke. Cerebrovascular Diseases 2008
- Neuroprotective and neuroproliferative activities of NeuroAiD (MLC601, MLC901),
a Chinese medicine, in vitro and in vivo. Neuropharmacology. 2010 - MLC901, a traditional Chinese medicine protects the brain against global ischemia.
Neuropharmacology. 2011 - NeuroAiD, a traditional Chinese medicine, in post stroke recovery.Stroke. 2009
- Safety and efficacy of MLC601 in Iranian patients after stroke: a double-blind, Placebo-controlled clinical trial.Stroke Research and Treatment. 2011
- NeuroAiD in Stroke Recovery European Neurology. 2008
- The effect of NeuroAiD™ (MLC601) on cerebral blood flow velocity in subjects’ post brain infarct in the middle cerebral artery territory.European Journal of Internal Medicine.2011
- Case report on the use of MLC 601 (NeuroAiD) in neurosurgical pathologies.Poster presented at the World Stroke Congress in Seoul. 2010
- NeuroAiD (MLC601) versus piracetam in the recovery of post-infarct homonymous hemianopsia. Neural Regeneration Research. 2011
- A double-blind, placebo-controlled, randomized, multicenter study to investigate
Chinese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES Study) generic zithromax australia. International
Journal of Stroke. 2009 - Safety Profile of MLC601 (NeuroAiD ) in Acute Ischemic Stroke Patients: A Singaporean Substudy of the Chinese Medicine NeuroAiD Efficacy on Stroke Recovery Study. Cerebrovascular Diseases. 2010
- NeuroAiD does not modify hemostasis, hematology, and biochemistry in normal subjects and stroke patients.Cerebrovascular Diseases. 2008.
- A double-blind, placebo-controlled, randomized phase II pilot study to investigate the
potential efficacy of the traditional Chinese medicine Neuroaid (MLC 601) in enhancing
recovery after stroke (TIERS).Cerebrovascular Diseases. 2009
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